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ca.lee@northeastern.edu

Faculty Profile

Carolyn W.T. Lee-Parsons

Associate Professor, Chemical Engineering
Interdisciplinary with, Chemistry & Chemical Biology
Affiliated Faculty, Bioengineering
617.373.3634
335 Mugar
360 Huntington Avenue
Boston, MA 02115

Biography

Joined the Chemical Engineering Department in Fall 1999.

My research is in biochemical engineering, specifically the area of metabolic engineering. Metabolic engineering embodies the principles, framework, and methodologies for understanding and manipulating the metabolic pathways in the cell for targeted and improved chemical transformations. My research group and I are applying metabolic engineering principles and methodologies to improve the production of important compounds from plants or plant cell cultures. Our research relies heavily on understanding the complex network of biosynthetic reactions within the cell and the application of tools in analytical chemistry for unveiling the secrets of the cell. The outcome of this research is an understanding of how to rationally direct the resources of the cell (i.e. precursor and energy fluxes) for significant enhancements in the production of the desired chemical compound. Our research is being applied to address:

Focus 1: the production of cost-prohibitive pharmaceutical compounds from cell cultures of plants.
Focus 2: the growing problem of antibiotic resistance using plant-derived compounds to inhibit bacterial defense mechanisms.
Focus 3: the efficient cultivation of plants with high nutritional quality for food, in environments with limited gas exchange such as those found on space stations

My main research focus is the production of valuable pharmaceutical compounds from plant cell cultures, specifically the production of important anti-cancer drug molecules from cell cultures of Catharanthus roseus. Plant cell culture is potentially a better route for supplying certain structurally complex drug molecules than chemical synthesis or extraction from whole plants. Moreover, plant cell culture can potentially produce these drug molecules at a faster and more consistent rate than whole plants. The overall vision of my research is to meet the needs and demands of important and cost-prohibitive plant-derived pharmaceuticals using plant cell culture, applying metabolic engineering strategies and ultimately developing an economically viable process using plant cell culture.

Education

  • 1995 PhD (Chemical Engineering), Cornell University, Advisor: Prof. Michael L. Shuler
  • BS (Chemical Engineering), University of Kansas Summa cum laude

Research & Scholarship Interests

Production of valuable pharmaceutical compounds from plant cell cultures, specifically the production of important anti-cancer drug molecules from cell cultures of Catharanthus roseus
Affiliated With

Department Research Areas

College Research Initiatives

Honors & Awards

  • NSF CAREER Award

Selected Publications

  • L. Kirchner, A. Wirshing, L. Kurt, T. Reinard, J. Glick, E.J. Cram, H-J. Jacobsen, C.W.T. Lee-Parsons, Identification, Characterization, and Expression of Diacylglycerol Acyltransferase Type-1 from Chlorella vulgaris, Algal Research, 13, 2016, 167-181
  • N.F. Rizvi, J. Weaver, E.J. Cram, C.W.T. Lee-Parsons, Silencing the Transcriptional Repressor, ZCT1, Illustrates the Tight Regulation of Terpenoid Indole Alkaloid Biosynthesis, PLoS ONE, 11(7), 2016, e0159712
  • N. Rizvi, M. Cornejo, K. Stein, J. Weaver, E.J. Cram, C.W.T. Lee-Parsons, An Efficient Transformation Method for Estrogen-Inducible Transgene Expression in Catharanthus roseus Hairy Roots, Plant Cell, Tissue and Organ Culture (PCTOC), 120(2), 2015, 475-487
  • J. Weaver, S. Goklany, N. Rizvi, E.J. Cram, C.W.T. Lee-Parsons, Optimizing the Transient Fast Agro-Mediated Seedling Transformation (FAST) Method in Catharanthus roseus Seedlings, Plant Cell Reports, 33(1), 2014, 89-97
  • S. Goklany, N. Rizvi, R.H. Loring, E.J. Cram, C.W.T. Lee-Parsons, Jasmonate-Dependent Alkaloid Biosynthesis in Catharanthus roseus is Correlated with the Relative Expression of Orca and Zct Transcription Factors, Biotechnology Progress, 29(6), 2013, 1367-1376
  • N. Rizvi, S. Goklany, E.J. Cram, C.W.T. Lee-Parsons, Rapid Increases of Key Regulators Precede the Increased Production of Pharmaceutically Valuable Compounds in Catharanthus roseus, Pharmaceutical Engineering, 33(6), 2013, 1-8
See Google Scholar Profile for all publications »

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May 1, 2018

Congratulations to all the winners of the faculty and staff awards, and to everyone for their hard work and dedication during the 2017-2018 academic school year. Faculty Fellow Guohao Dai, BioE...

June 8, 2017

ChE/COS Associate Professor Carolyn W.T. Lee-Parsons was featured in the Belmont Patch after giving the Keynote Speech at the Interdisciplinary Plant Science Symposium.

May 18, 2017

After over a year of research, ChE BS/MS student Deb Pano and Postdoctoral Research Associate Dr. Diana Bernal-Franco were awarded an Endeavor Grant from Northeastern University. Both Ms. Pano and Dr...

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