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a.koppes@northeastern.edu

Faculty Profile

Biography

Joined the Chemical Engineering Department in Fall 2014.

The main focus of the Advanced Biomaterials for NeuroEngineering Laboratory (ABNEL) is advancing treatments for persons suffering from debilitating disorders and injuries of the central and peripheral nervous system. Using a combinatorial approach, we seek to create therapeutic strategies for improved nerve guidance channels that incorporate biomaterial manufacturing, biophysical (optogenetics) cues, structural (nanotopography) cues, and/or biochemical (cytokine) stimulation to modulate neuronal and non-neuronal support cell behavior. We are interested in probing the underlying mechanisms of neural growth and regeneration while engineering future modalities for neural tissue engineering applications.

Through tissue engineering of the enteric nervous system, the ‘Brain in the Gut,’ we hope to improve drug discovery platforms and regenerative medicine interventions for the millions of people suffering from disorders of the gastrointestinal tract, such as irritable bowel diseases. This work will combine primary small intestinal organoid culture with neuro-engineering techniques to recapitulate this complex biological system. Ultimately, we aim to understand the underlying mechanisms of cellular responses to engineered systems and their native biological niches towards rationally designed therapies. Our research utilizes techniques from bioengineering, chemical engineering, materials science, and cellular, molecular, and systems biology.

Education

  • B.S. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2007
  • M.S. (Biomedical Engineering) Rensselaer Polytechnic Institute, 2010
  • PhD (Biomedical Engineering) Rensselaer Polytechnic Institute, 2013

Research & Scholarship Interests

Bioelectric medicine, development of novel interventions and tissue engineered platforms for nerve regeneration and repair
Affiliated With

Department Research Areas

Selected Publications

  • A.N. Koppes, M. Kamath, C. Pfluger, D. Burkey, M.R. Dokmeci,  L. Wang, R.L. Carrier, Complex, Multi-Scale Small Intestinal Topography Replicated in Cellular Growth Substrates Fabricated via Chemical Vapor Deposition of Parylene C, Biofabrication, 8, 2016, 035011
  • A.N. Koppes, K.W. Keating, A.L. McGregor, R.A. Koppes, K.R. Kearns, A.M. Ziemba, C.A. McKay, J.M. Zuidema, C.J. Rivet,   R.J. Gilbert, D.M. Thompson, Robust Neurite Extension Following Exogenous Electrical Stimulation within Single Walled Carbon Nanotube-Composite Hydrogels, Acta Biomaterialia, 39, 2016, 34-43
  • D. Ventre, A.N. Koppes, The Body Acoustic: Ultrasonic Neuromodulation for Translational Medicine, Cells, Tissues, and Organs, 202, 2015-16, 23-41
  • S. Hosic, S.K. Murthy, A.N. Koppes, Microfluidic Sample Preparation for Single Cell Analysis, Analytical Chemistry, 88(1), 2015, 354-380
  • A.N. Koppes, D.M. Thompson, Neural Innervation of Engineered Musculoskeletal Tissues, Regenerative Engineering of Musculoskeletal Tissues and Interfaces, 2015, 293-323
  • D.M. Thompson, A.N. Koppes, J.G. Hardy, C.E. Schmidt, Electrical Stimuli in the Central Nervous System Microenvironment, Annual Review of Biomedical Engineering,16, 2014, 397-430
  • A.N. Koppes, N.W. Zaccor, C.J Rivet, L.A. Williams, J.M. Piselli, R.J. Gilbert, D.M. Thompson, Neurite Outgrowth on Electrospun PLLA Fibers is Enhanced by Exogenous Electrical Stimulation, Journal of Neural Engineering, 11(4), 2014, 046002
  • D.M. Thompson, A.N. Koppes, J.G. Hardy, C.E. Schmidt, Electrical Stimulation of the CNS Microenvironment, Annual Review of Biomedical Engineering, 16, 2014, 397-430
See Google Scholar Profile for all publications »

Related News

June 15, 2018

ChE Assistant Professor Abigail Koppes was nominated by the New PI community (new PI slack) of over 900 folks worldwide as “ Featured new PI ” for the month of June...

May 15, 2018

The first International Conference on Biomaterials and Chemical Biology was hosted at Northeastern University by the Department of Chemical Engineering. Collaborative research in these disciplines has the potential to advance the field of biomaterials in a unique way and lead to new discoveries for better medicines and treatments. Additionally, Xingdong Zhang, Professor and Honorary Director of the National Engineering Research Center for Biomaterials at Sichuan University, was named University Distinguished Professor by Provost James Bean and Dean Nadine Aubry.

December 15, 2017

Bioengineering student Minhal Ahmed '19 was awarded the Undergraduate Advanced Research/Creative Endeavor Award for his research project entitled, "The Gut-Brain-Axis: Exploring the Interface Between Enteroendocrine Cells and the Enteric Nervous System".