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r.carrier@northeastern.edu

Faculty Profile

Rebecca L. Carrier

Associate Professor & Associate Chair of Research, Chemical Engineering
Affiliated Faculty, Bioengineering
617.373.7126
208 Lake Hall
43 Leon Street
Boston, MA 02115

Biography

Joined the Chemical Engineering Department in Fall 2003.

The overall theme of my research interests is the interaction between biological systems and materials, with specific applications in drug delivery and regenerative medicine. The two main goals of my research program are: 1. To enhance understanding of compound transport in biological systems, (e.g., drug transport through the body), and how it is influenced by exogenous and endogenous carrier systems (e.g., lipid micelles) and 2. To develop and study biomimetic biomaterials and cellular response to them. Quantitative, mechanistic understanding of compound transport in the body will enable rational design of drug delivery systems, streamlining the resource-intensive drug development process and enabling viable pharmaceutical products to be developed from promising drug candidates. It could also enhance understanding of physiological function (e.g., significance of biological barriers such as gastrointestinal mucus in normal and disease states). Precisely biomimetic biomaterials could enable meaningful cell culture models for research and scaffolds promoting tissue regeneration when combined with appropriate cells. Current specific research focus areas include the impact of lipids on oral compound absorption, mechanistic studies of mucus barriers to drug and drug carrier transport, and development of biomimetic biomaterials for intestinal and retinal tissue engineering.

Education

  • PhD (Chemical Engineering) Massachusetts Institute of Technology, 2000
  • BS Rensselaer Polytechnic Institute, 1995

Research & Scholarship Interests

Interaction between biological systems and materials, with specific applications in drug delivery and regenerative medicine; intestinal and retinal engineering; oral lipid systems
Affiliated With

Department Research Areas

College Research Initiatives

Honors & Awards

  • 2014 COE Faculty Fellow
  • 2008 NSF CAREER Award

Selected Publications

  • H.M. Yildiz, L. Speciner, C. Ozdemir, D.E. Cohen, R.L. Carrier, Food-associated Stimuli Enhance Barrier Properties of Gastrointestinal Mucus, Biomaterials, 54, 2015, 1-8
  • H.M. Yildiz, T.L. Carlson, A.M. Goldstein, R.L. Carrier, Mucus Barriers to Microparticles and Microbes are Altered in Hirschsprung’s Disease, Macromol Biosci, 5(5), 2015, 712-718
  • P. Baranov, A. Michaelson, J. Kundu, R.L. Carrier, M. Young, Interphotoreceptor Matrix-poly(caprolactone) Composite Scaffolds for Human Photoreceptor Differentiation, Journal of Tissue Engineering, 5, 2014
  • C.A. Pfluger, B.J. McMahon, R.L. Carrier, D.D. Burkey, Precise, Biomimetic Replication of the Multiscale Structure of Intestinal Basement Membrane using Chemical Vapor Deposition, Tissue Engineering, 19(5-6), 2013, 649-656
  • S. diMaio, R.L. Carrier, Gastrointestinal Contents Post-lipid Ingestion: In vivo Measurements and in Vitro Models for Studying Oral Drug Delivery, Journal of Controlled Release, 151(2), 2011, 110-122
See Google Scholar Profile for all publications »

Related News

November 30, 2016

BioE PhD candidate Jaclyn Lock, advised by ChE Associate Professor Rebecca Carrier, was awarded first place in the AIChE Materials Engineering & Sciences Division (MESD) poster competition.

September 13, 2016

ChE Associate Professor Rebecca Carrier (PI) and Assistant Professor Abigail Koppes (co-I) were awarded a $5M NIH Bioengineering Research Partnership grant entitled “GuMI: New In Vitro Platforms to Parse the Human Gut Epithelial-Microbiome-Immune Axis.”

August 24, 2016

ChE Associate Professor Rebecca Carrier was awarded a $450K NSF grant for "Uncovering Regeneration-Permissive Cues in Lower Vertebrate Retina to Inform Retinal Regenerative Medicine"...

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