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Faculty Profile


Joined the Chemical Engineering Department in Fall 2003.

The overall theme of my research interests is the interaction between biological systems and materials, with specific applications in drug delivery and regenerative medicine. The two main goals of my research program are: 1. To enhance understanding of compound transport in biological systems, (e.g., drug transport through the body), and how it is influenced by exogenous and endogenous carrier systems (e.g., lipid micelles) and 2. To develop and study biomimetic biomaterials and cellular response to them. Quantitative, mechanistic understanding of compound transport in the body will enable rational design of drug delivery systems, streamlining the resource-intensive drug development process and enabling viable pharmaceutical products to be developed from promising drug candidates. It could also enhance understanding of physiological function (e.g., significance of biological barriers such as gastrointestinal mucus in normal and disease states). Precisely biomimetic biomaterials could enable meaningful cell culture models for research and scaffolds promoting tissue regeneration when combined with appropriate cells. Current specific research focus areas include the impact of lipids on oral compound absorption, mechanistic studies of mucus barriers to drug and drug carrier transport, and development of biomimetic biomaterials for intestinal and retinal tissue engineering.


  • PhD (Chemical Engineering) Massachusetts Institute of Technology, 2000
  • BS Rensselaer Polytechnic Institute, 1995

Research & Scholarship Interests

Interaction between biological systems and materials, with specific applications in drug delivery and regenerative medicine; intestinal and retinal engineering; oral lipid systems
Affiliated With

Department Research Areas

College Research Initiatives

Honors & Awards

  • 2017 Søren Buus Outstanding Research Award
  • 2016 NAE Frontiers of Engineering Symposium
  • 2014 COE Faculty Fellow
  • 2013 NAE Frontiers of Engineering Education Symposium
  • 2008 NSF CAREER Award

Selected Publications

  • A.N. Koppes, M. Kamath, C.A. Pfluger, D.D. Burkey, M. Dokmeci, L. Wang, R.L. Carrier, Complex, Multi-Scale Small Intestinal Topography Replicated in Cellular Growth Substrates Fabricated via Chemical Vapor Deposition of Parylene C, Biofabrication, 8(3), 2016, 035011
  • J. Kundu, A. Michaelson, K. Talbot, P. Baranov, M.J. Young, R.L. Carrier, Decellularized Retinal Matrix: Natural Platforms for Human Retinal Progenitor Cell Culture, Acta Biomaterialia, 31, 2016, 61-70
  • O. Rezhdo, L. Speciner, R.L. Carrier, Lipid-associated Oral Delivery: Mechanisms and Analysis of Oral Absorption, Journal of Controlled Release, 240, 2016, 544-560
  • H.M. Yildiz, L. Speciner, C. Ozdemir, D.E. Cohen, R.L. Carrier, Food-Associated Stimuli Enhance Barrier Properties of Gastrointestinal Mucus, Biomaterials, 54, 2015, 1-8
  • H.M. Yildiz, T.L. Carlson, A.M. Goldstein, R.L. Carrier, Mucus Barriers to Microparticles and Microbes are Altered in Hirschsprung’s Disease, Macromol Biosci, 5(5), 2015, 712-718
  • J.R. Thiagarajah, H. Yildiz, T. Carlson, A.R. Thomas, C. Steiger,  A. Pieretti, L.R. Zuckerberg, R.L. Carrier, A.M. Goldstein, Altered Goblet Cell Differentiation and Surface Mucus Properties in Hirschsprung Disease, PLoS ONE, 9(6), 2014, e99944
  • P. Baranov, A. Michaelson, J. Kundu, R.L. Carrier, M. Young, Interphotoreceptor Matrix-poly(caprolactone) Composite Scaffolds for Human Photoreceptor Differentiation, Journal of Tissue Engineering, 5, 2014
See Google Scholar Profile for all publications »

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