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r.carrier@northeastern.edu

Profile

Biography

Joined the Chemical Engineering Department in Fall 2003.

The overall theme of my research interests is the interaction between biological systems and materials, with specific applications in drug delivery and regenerative medicine. The two main goals of my research program are: 1. To enhance understanding of compound transport in biological systems, (e.g., drug transport through the body), and how it is influenced by exogenous and endogenous carrier systems (e.g., lipid micelles) and 2. To develop and study biomimetic biomaterials and cellular response to them. Quantitative, mechanistic understanding of compound transport in the body will enable rational design of drug delivery systems, streamlining the resource-intensive drug development process and enabling viable pharmaceutical products to be developed from promising drug candidates. It could also enhance understanding of physiological function (e.g., significance of biological barriers such as gastrointestinal mucus in normal and disease states). Precisely biomimetic biomaterials could enable meaningful cell culture models for research and scaffolds promoting tissue regeneration when combined with appropriate cells. Current specific research focus areas include the impact of lipids on oral compound absorption, mechanistic studies of mucus barriers to drug and drug carrier transport, and development of biomimetic biomaterials for intestinal and retinal tissue engineering.

Education

  • PhD (Chemical Engineering) Massachusetts Institute of Technology, 2000
  • BS Rensselaer Polytechnic Institute, 1995

Research & Scholarship Interests

intestinal tissue engineering, retinal regenerative medicine, oral drug delivery
Affiliated With

Department Research Areas

College Research Initiatives

Honors & Awards

  • 2017 Søren Buus Outstanding Research Award
  • 2016 NAE Frontiers of Engineering Symposium
  • 2014 COE Faculty Fellow
  • 2013 NAE Frontiers of Engineering Education Symposium
  • 2008 NSF CAREER Award

Selected Publications

  • J. Kundu, A. Michaelson, P. Baranov, M. Chiumiento, T. Nigl, M.J.Young, R.L. Carrier, Interphotoreceptor Matrix Based Biomaterial: Impact on Human Retinal Progenitor Cell Attachment and Differentiation, Journal of Biomedical Materials Research B Applied Biomaterials, 106(2), 2018, 891-899
  • J.Y. Lock, T.L. Carlson, C.M. Wang, A. Chen, R.L. Carrier, Acute Exposure to Commonly Ingested Emulsifiers Alters Intestinal Mucus Structure and Transport Properties, Scientific Reports, 8(1), 2018,10008
  • T.L. Carlson J.Y. Lock R.L. Carrier, Engineering the Mucus Barrier, Annual Reviews in Biomedical Engineering, 20, 2018, 197-220
  • et al, R.L. Carrier, M. Cirit, L.G. Griffith, D.A. Lauffenburger, Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk, Biotechnology and Bioengineering,114(11), 2017, 2648-2659
  • A.N. Koppes, M. Kamath, C.A. Pfluger, D.D. Burkey, M. Dokmeci, L. Wang, R.L. Carrier, Complex, Multi-Scale Small Intestinal Topography Replicated in Cellular Growth Substrates Fabricated via Chemical Vapor Deposition of Parylene C, Biofabrication, 8(3), 2016, 035011O
  • Rezhdo, L. Speciner, R.L. Carrier, Lipid-associated Oral Delivery: Mechanisms and Analysis of Oral Absorption, Journal of Controlled Release, 240, 2016, 544-560
See Google Scholar Profile for all publications »

Related News

December 3, 2018

ChE Professor and Associate Chair of Research Rebecca Carrier has been elected as a fellow of the American Institute of Medical and Biological Engineering (AIMBE) for her exceptional achievements and significant contributions within the medical and biological engineering fields.

October 18, 2018

ChE Professor Rebecca Carrier was awarded a four-year $1.57M renewal NIH grant for "Impact of lipids and food on oral compound absorption: mechanistic studies and modeling." Abstract Source...

September 6, 2018

The Department of Chemical Engineering is proud to announce that eight of their students have received the Northeastern University Research and Creative Endeavor Awards from the Office of Undergraduate Research and Fellowships.

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