ChE Professor Rebecca Carrier was awarded a patent for a "Device for controlled apical flow in cell culture inserts." Abstract Source: USPTO A device for controlling apical flow to a cell...
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- PhD (Chemical Engineering) Massachusetts Institute of Technology, 2000
- BS Rensselaer Polytechnic Institute, 1995
- 2017 Søren Buus Outstanding Research Award
- 2016 NAE Frontiers of Engineering Symposium
- 2014 COE Faculty Fellow
- 2013 NAE Frontiers of Engineering Education Symposium
- 2008 NSF CAREER Award
- J. Kundu, A. Michaelson, P. Baranov, M. Chiumiento, T. Nigl, M.J.Young, R.L. Carrier, Interphotoreceptor Matrix Based Biomaterial: Impact on Human Retinal Progenitor Cell Attachment and Differentiation, Journal of Biomedical Materials Research B Applied Biomaterials, 106(2), 2018, 891-899
- J.Y. Lock, T.L. Carlson, C.M. Wang, A. Chen, R.L. Carrier, Acute Exposure to Commonly Ingested Emulsifiers Alters Intestinal Mucus Structure and Transport Properties, Scientific Reports, 8(1), 2018,10008
- T.L. Carlson J.Y. Lock R.L. Carrier, Engineering the Mucus Barrier, Annual Reviews in Biomedical Engineering, 20, 2018, 197-220
- et al, R.L. Carrier, M. Cirit, L.G. Griffith, D.A. Lauffenburger, Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk, Biotechnology and Bioengineering,114(11), 2017, 2648-2659
- A.N. Koppes, M. Kamath, C.A. Pfluger, D.D. Burkey, M. Dokmeci, L. Wang, R.L. Carrier, Complex, Multi-Scale Small Intestinal Topography Replicated in Cellular Growth Substrates Fabricated via Chemical Vapor Deposition of Parylene C, Biofabrication, 8(3), 2016, 035011O
- Rezhdo, L. Speciner, R.L. Carrier, Lipid-associated Oral Delivery: Mechanisms and Analysis of Oral Absorption, Journal of Controlled Release, 240, 2016, 544-560
Joined the Chemical Engineering Department in Fall 2003.
The overall theme of my research interests is the interaction between biological systems and materials, with specific applications in drug delivery and regenerative medicine. The two main goals of my research program are: 1. To enhance understanding of compound transport in biological systems, (e.g., drug transport through the body), and how it is influenced by exogenous and endogenous carrier systems (e.g., lipid micelles) and 2. To develop and study biomimetic biomaterials and cellular response to them. Quantitative, mechanistic understanding of compound transport in the body will enable rational design of drug delivery systems, streamlining the resource-intensive drug development process and enabling viable pharmaceutical products to be developed from promising drug candidates. It could also enhance understanding of physiological function (e.g., significance of biological barriers such as gastrointestinal mucus in normal and disease states). Precisely biomimetic biomaterials could enable meaningful cell culture models for research and scaffolds promoting tissue regeneration when combined with appropriate cells. Current specific research focus areas include the impact of lipids on oral compound absorption, mechanistic studies of mucus barriers to drug and drug carrier transport, and development of biomimetic biomaterials for intestinal and retinal tissue engineering.
Research & Scholarship Interests
Department Research Areas
College Research Initiatives
Honors & Awards
ChE Professor and Associate Chair of Research Rebecca Carrier has been elected as a fellow of the American Institute of Medical and Biological Engineering (AIMBE) for her exceptional achievements and significant contributions within the medical and biological engineering fields.
ChE Professor Rebecca Carrier was awarded a four-year $1.57M renewal NIH grant for "Impact of lipids and food on oral compound absorption: mechanistic studies and modeling." Abstract Source...
65 Landsdowne St, Cambridge, MA