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s.murthy@neu.edu

Faculty Profile

Shashi Murthy

Associate Professor, Chemical Engineering
Affiliated Faculty, Bioengineering
617.373.4017
8 Hayden Hall
360 Huntington Avenue
Boston, MA 02115

Biography

The primary focus of our research is the design of microfluidic devices for applications in clinical diagnostics and regenerative medicine. These devices are fabricated using technology originally designed for the semiconductor industry and are capable of handling and manipulating small volumes of fluids (down to tens of microliters) and small numbers of cells. Our expertise is in functionalizing microfluidic channels with a broad range of biomolecules and achieving high-resolution cell separation with these simple and easy-to-use devices.

Education

  • B.S. (Chemical Engineering) Johns Hopkins University, 1999
  • Ph.D. (Materials Science and Engineering) Massachusetts Institute of Technology, 2003
  • Postdoctoral Fellowship Harvard Medical School and Massachusetts General Hospital, 2003-2005

Research & Scholarship Interests

Microfluidic isolation of stem and progenitor cells, point-of-care diagnostics, cell surface phenomena during microfluidic flow, nanoscale probes for cell stimulation, and biopassive/bioactive coatings for neurological implants
Affiliated With

Department Research Areas

College Research Initiatives

Honors & Awards

  • College of Engineering Faculty Fellow
  • National Science Foundation CAREER Award
  • Søren Buus Outstanding Research Award

Selected Publications

  • “Design, Validation, and Clinical Application of an Endothelial Progenitor Cell Microfluidic Capture Chip in Patients with Cardiovascular Disease,” G. Hansmann, B.D. Plouffe, A. Hatch, A. von Gise, H. Sallmon, R.T. Zamanian, and S.K. Murthy. Journal of Molecular Medicine (in press; 2011).
  • “Thermomagnetic Determination of Fe3O4 Magnetic Nanoparticle Diameters for Biomedical Applications,” B.D. Plouffe, D.K. Nagesha, R.S. DiPietro, S. Sridhar, D. Heiman, S.K. Murthy, and L.H. Lewis. Journal of Magnetism and Magnetic Materials 2011 (published online).
  • “Computational Design Optimization for Microfluidic Magnetophoresis,” B.D. Plouffe, L.H. Lewis, and S.K. Murthy. Biomicrofluidics 5, 013413 (2011).
  • “Lectin-Mediated Microfluidic Capture and Release of Leukemic Lymphocytes from Whole Blood,” D.A.L. Vickers, M. Hincapie, W.S. Hancock, and S.K. Murthy. Biomedical Microdevices 13, 565-571 (2011).
  • “Microfluidic Pillar Array Sandwich Immunofluorescence Assay for Ocular Diagnostics,” J.V. Green, D. Sun, A. Hafezi-Moghadam, K. Lashkari, and S.K. Murthy. Biomedical Microdevices 13, 573-583 (2011).
  • “Engineered Alginate Hydrogels for Effective Microfluidic Capture and Release of Endothelial Progenitor Cells from Whole Blood,” A. Hatch, G. Hansmann, and S.K. Murthy. Langmuir 27, 4257-4264 (2011).
  • “Molecular Mechanochemistry: Strain-Dependent Enzymatic Cleavage of Human Type I Collagen Monomer,” R.J. Camp, M. Lilies, J. Beale, N. Saedi, B. Flynn, E. Moore, S.K. Murthy, and J.W. Ruberti. Journal of the American Chemical Society 133, 4073-4078 (2011).
  • “Receptor Expression Changes as a Basis for Endothelial Cell Identification Using Microfluidic Channels,” D.A.L. Vickers and S.K. Murthy. Lab on a Chip 10, 2380-2386 (2010).
  • “Synergic Effects of Crypt-like Topography and ECM Proteins on Intestinal Cell Behavior in Collagen Based Membranes,” L. Wang, S.K. Murthy, G.A. Barabino, and R.L. Carrier. Biomaterials 31, 7586-7598 (2010).
  • “Biocompatibility Assessment of Insulating Silicone Polymer Coatings Using an In Vitro Glial Scar Assay,” A.K.H. Achyuta, V.S. Polikov, A.J. White, H.G. Pryce Lewis, and S.K. Murthy. Macromolecular Bioscience 10, 872-880 (2010).
  • “Bridging the Divide Between Neuroprosthetic Design, Tissue engineering, and Neurobiology,” J.B. Leach, A.K.H. Achyuta, and S.K. Murthy. Frontiers in Neuroengineering (invited review article; available online).
  • “Mitigation of Reactive Human Cell Adhesion on Poly(dimethylsiloxane) by Immobilized Trypsin,” A.K.H. Achyuta, K.D. Stephens, H.G. Pryce Lewis, and S.K. Murthy. Langmuir 26, 4160–4167 (2010).
  • “Deterministic Lateral Displacement as a Means to Enrich Large Cells for Tissue Engineering,” J.V. Green, M. Radisic, and S.K. Murthy. Analytical Chemistry 81, 9178-9182 (2009).
  • “Influence of Micro-well Biomimetic Topography on Intestinal Epithelial Caco-2 Cell Phenotype,” L. Wang, S.K. Murthy, W.H. Fowle, G.A. Barabino, and R.L. Carrier. Biomaterials 30, 6825-6834 (2009).
  • “Development of Microfluidics as Endothelial Progenitor Cell Capture Technology for Cardiovascular Tissue Engineering and Diagnostic Medicine,” B.D. Plouffe, T. Kniazeva, J.E. Mayer, S.K. Murthy, and V.L. Sales. FASEB Journal 23, 3309-3314 (2009). ** Featured in press release and local TV news media.**
  • “Microfluidic Enrichment of a Target Cell Type from a Heterogenous Suspension by Adhesion-Based Negative Selection,” J.V. Green and S.K. Murthy. Lab on a Chip 9, 2245-2248 (2009).
  • “Controlled Capture and Release of Cardiac Fibroblasts using Peptide-Functionalized Alginate Gels in Microfluidic Channels,” B.D. Plouffe, M.A. Brown, R.K. Iyer, M. Radisic, and S.K. Murthy. Lab on a Chip, 9, 1507-1510 (2009). ** Featured as ‘Hot Article’ by journal.**
  • “Incorporation of Linear Spacer Molecules in Vapor Deposited Silicone Polymer Thin Films,” A.K.H. Achyuta, A.J. White, H.G. Pryce Lewis, and S.K. Murthy. Macromolecules 42, 1970-1978 (2009).
  • “Functionalization-Induced Improvement in Magnetic Properties of Fe3O4 Nanoparticles for Biomedical Applications,” D.K. Nagesha, B.D. Plouffe, M. Phan, L.H. Lewis, S. Sridhar, and S.K. Murthy. Journal of Applied Physics 105, 07B317 (2009).
  • “Effect of Channel Geometry on Cell Adhesion in Microfluidic Devices,” J.V. Green, T. Kniazeva, M. Abedi, D. Sokhey, M.E. Taslim, and S.K. Murthy. Lab on a Chip 9, 677-685 (2009).
  • “Synergistic Effect of Immobilized Laminin and Nerve Growth Factor on PC12 Neurite Outgrowth,” A.K.H. Achyuta, R. Cieri, K. Unger, and S.K. Murthy. Biotechnology Progress 25, 227-234 (2009).
  • “Microfluidic Depletion of Endothelial Cells, Smooth Muscle Cells, and Fibroblasts from Heterogeneous Suspensions,” B.D. Plouffe, M. Radisic, and S.K. Murthy. Lab on a Chip 8, 462 (2008).
  • “Nanoparticles in Modern Medicine: State of the Art and Future Challenges,” S.K. Murthy. International Journal of Nanomedicine 2, 129-141 (2007).
  • “Peptide-Mediated Selective Adhesion of Smooth Muscle and Endothelial Cells in Microfluidic Shear Flow,” B.D. Plouffe, D.N. Njoka, J. Harris, J. Liao, N.K. Horick, M. Radisic, and S.K. Murthy. Langmuir 23, 5050 (2007).
  • “Size-Based Microfluidic Enrichment of Neonatal Rat Cardiac Cell Populations,” S.K. Murthy, P. Sethu, G. Vunjak-Novakovic, M. Toner, and M. Radisic, Biomedical Microdevices 8, 231 (2006).
  • “Micro- and Nano-technology in Cell Separation,” M. Radisic, R.K. Iyer, and S.K. Murthy. International Journal of Nanomedicine 1, 3 (2006).
  • “Enrichment Using Antibody Coated Microfluidic Chambers in Shear Flow: Model Mixtures of Human Lymphocytes,” A. Sin, S.K. Murthy, A. Revzin, R.G. Tompkins, and M. Toner. Biotechnology and Bioengineering 91, 816 (2005).
  • “Effect of Flow and Surface Conditions on Human Lymphocyte Isolation Using Microfluidic Chambers,” S.K. Murthy, A. Sin, R.G. Tompkins, and M. Toner. Langmuir 20, 11649 (2004).
  • “Peptide Attachment to Vapor Deposited Polymeric Thin Films,” S.K. Murthy, B.D. Olsen, and K.K. Gleason. Langmuir 20, 4774 (2004).
  • “Vapor Deposition of Biopassivation Coatings for Neuroprostheses.” S.K. Murthy, D.J. Edell, and K.K. Gleason. In Neuroprosthetics: Theory and Practice, K.W. Horch and G. Dhillon, Editors; World Scientific Publishing: Singapore (2004).
  • “Effect of Filament Temperature on the Chemical Vapor Deposition of Fluorocarbon-Organosilicon Copolymers.” S.K. Murthy, B.D. Olsen, and K.K. Gleason. Journal of Applied Polymer Science 91, 2176 (2004).
  • “Making Thin Polymeric Materials Including Fabrics Microbicidal and also Water-Repellent,” J. Lin, S.K. Murthy, B.D. Olsen, K.K. Gleason, and A.M. Klibanov. Biotechnology Letters 25, 1661 (2003).
  • “Fluorocarbon Dielectrics via Hot Filament Chemical Vapor Deposition,” K.K.S. Lau, S.K. Murthy, H.G. Pryce Lewis, J.A. Caulfield, and K.K. Gleason. Journal of Fluorine Chemistry 122, 93 (2003).
  • “Initiation of Cyclic Vinylmethylsiloxane Polymerization in a Hot-Filament Chemical Vapor Deposition Process,” S.K. Murthy, B.D. Olsen, and K.K. Gleason. Langmuir 18, 6424 (2002).
  • “Fluorocarbon-Organosilicon Copolymer Synthesis by Hot Filament Chemical Vapor Deposition,” S.K. Murthy and K.K. Gleason. Macromolecules 35, 1967 (2002).

Related News

November 12, 2014

Learn about David Walsh-- a fourth year PhD bioengineering student and NSF Graduate Research Fellow.

October 14, 2014

ChE Associate Professor Shashi Murthy’s research on “Microfluidic Isolation of CD34-Positive Skin Cells Enables Regeneration of Hair and Sebaceous Glands In Vivo” is featured on the November cover of Stem Cells Translational Medicine.

September 24, 2014

ChE Associate Professor Shashi Murthy & MIE Assistant Professor Marilyn Minus were invited to represent Northeastern at the National Academy of Engineering’s Frontiers of Engineering Education Symposium.