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The Asthagiri lab elucidates design principles for engineering living cells and tissues. These design principles provide a foundation for tissue engineering and regenerative medicine. The implications extend beyond engineering artificial organ replacements. Synthetic multicellular structures that mimic their natural counterparts provide better platforms for drug discovery and screening. In addition, elucidating how multicellular structures assemble provides deeper insights into how these structures fall apart in diseases, such as cancer. Understanding the disassembly of multicellular structures sheds new insights into cancer development and helps to identify therapeutic strategies to re-shape diseased tissue.


  • B.S. with distinction (Chemical Engineering) Cornell University, 1995
  • Ph.D. (Chemical Engineering) Massachusetts Institute of Technology, 2000
  • Postdoctoral Fellow Harvard Medical School, 2000-2001

Research & Scholarship Interests

Elucidates design principles for engineering living cells and tissues.
Affiliated With

Department Research Areas

College Research Initiatives

Selected Publications

  • D.I. Walsh III, M.L. Lalli, J.M. Kassas, A.R. Asthagiri, S.K. Murthy, Cell Chemotaxis on Paper for Diagnostics, Analytical Chemistry, 87(11), 2015, 5505-5510
  • M.L. Lalli, A.R. Asthagiri, Collective Migration Exhibits Greater Sensitivity but Slower Dynamics of Alignment to Applied Electric Fields, Cellular and Molecular Bioengineering, 8(2), 2015, 247-257
  • J.H. Kim, L.J. Dooling, A.R. Asthagiri, Intercellular Mechanotransduction During Multicellular Morphodynamics, Royal Society Interface, 7(3), 2010, 341-350
  • K.S. Kushiro, A. Chang, A.R. Asthagiri, Reprogramming Directional Cell Motility by Tuning Micropattern Features and Cellular Signals, Advanced Materials, 22, 4516, 2010, 4516-4519
  • C.A. Giurumescu, A.R. Asthagiri, Systems Approaches to Developmental Patterning, Systems Biomedicine, Eds: Douglas A. Lauffenburger, Edison Liu and Garry Nolan, Elsevier Press, 2010
  • S.A. Chapman, A.R. Asthagiri, Quantitative Role of Scaffolding on Signal Propagation, Molecular Systems Biology, 5(313), 2009
  • C.A. Giurumescu, P.W. Sternberg, A.R. Asthagiri, Predicting Phenotypic Diversity and the Underlying Quantitative Molecular Transitions, PLoS Computational Biology, 5(4), 2009, 1-13
See Google Scholar Profile for all publications »

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