Webster Co-Authors New Book
Tom Webster, ChE Professor and Art Zafiropoulo Chair, co-authored the new book Immune Aspects of Biopharmaceuticals and Nanomedicines due for release April 30, 2018.
Abstract
The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have necessitated an authoritative and comprehensive reference that can be relied upon by immunologists, biomedical researchers, physicians, pharmaceutical and formulation scientists, clinicians, regulatory personnel, technology transfer officers, venture capitalists, and policy makers alike. This book provides a broad survey of various interconnected topics, all accomplished in a user‐friendly format. The chapters are devoted to the immune stimulatory and suppressive effects of antibodies, peptides and other biopharmaceuticals, drug carrier liposomes, micelles, polymers, polymeric vesicles, dendrimers, carbon nanotubes, and other nanomedicines (with and without surface targeting ligands). The text discusses the state of the art in nanoparticle‐formulated therapeutic and preventive vaccines along with their potential molecular mechanisms underlying immunogenicity. The latter phenomenon is addressed as an adverse effect of monoclonal antibody–based biopharmaceuticals and nanomedicines. Yet another adverse immune effect of monoclonals and nanomedicines, complement activation‐related pseudoallergy (CARPA), is discussed in unprecedented detail in terms of occurrence, prediction, prevention, and mechanism. The range of the contributing authors accurately reflects the diverse and rapidly evolving fields of biotherapeutics, nanomedicines, nanoimmunology, and nanotoxicology. The book’s multidisciplinary and in‐depth approach makes it a standard reference in this expansive and interdisciplinary field.